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KMID : 0376219720090010225
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Chonnam Medical Journal
1972 Volume.9 No. 1 p.225 ~ p.229
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The influence of ouabain on the renal function of the tortoise
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Abstract
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In this study an attempt was made to clarify the possible role of Na-Kactivated adenosine triphosphatase system in the reabsorption of sodium in tortoise (Amyda japonica) kidney. Ouabain, a potent inhibitor of the membrane enzyme in, various organisms was applied. Intravenously administered ouabain, in a dose of 3.34 μg/kg/min had no apparent renal effect.
Direct administration into a renal portal vein, however, elicited prominent and sustained natriuresis and kaluresis which were confined only to the infused side. In these experiments, the adequacy of infusion was ascertained by simultaneously measured apparent tubular extractron fraction(ATEF) of PAH,
It was suggested from these observations that the natriuresis and kaluresis after, ouabain may be resulted from the inhibition of Na-K-activated ATPase in tortoise renal tubules, and that the membrane ATPase system may play an important role in the sodium reabsorptive mechanism of tortoise kidney.
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